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1

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

Cameron, Ryan T., Coleman, Ryan G., Day, Jon P., Yalla, Krishna C., Houslay, Miles D., Adams, David R., Shoichet, Brian K., Baillie, George S.

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

2

Evolutionary genetics of personality in the Trinidadian guppy II: sexual dimorphism and genotype-by-sex interactions

White, Stephen John, Houslay, Thomas Miles, Wilson, Alastair James

Journal:

Year:

2019

Language:

english

File:

PDF, 1.09 MB

english, 2019

3

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

Miles D. Houslay

Journal:

Trends in Biochemical Sciences

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

4

Modelling the cAMP pathway using BioNessie, and the use of BVP techniques for solving ODEs

Xu Gu, David Gilbert, Des Higham, Miles Houslay

Journal:

BMC Systems Biology

Year:

2007

Language:

english

File:

PDF, 242 KB

english, 2007

5

Cell signalling: Dual control of adenylate cyclase

Journal:

Year:

1983

File:

PDF, 326 KB

1983

6

[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 ||

Francis, Sharron H., Conti, Marco, Houslay, Miles D.

Year:

2011

Language:

english

File:

PDF, 6.67 MB

english, 2011

7

PGE1Stimulation of HEK293 Cells Generates Multiple Contiguous Domains with Different [cAMP]: Role of Compartmentalized Phosphodiesterases

Anna Terrin, Giulietta Di Benedetto, Vanessa Pertegato, York-Fong Cheung, George Baillie, Martin J. Lynch, Nicola Elvassore, Anke Prinz, Friedrich W. Herberg, Miles D. Houslay and Manuela Zaccolo

Journal:

The Journal of Cell Biology

Year:

2006

Language:

english

File:

PDF, 1.91 MB

english, 2006

8

Regulation of hepatocyte adenylate cyclase by amylin and CGRP: A single receptor displaying apparent negative cooperativity towards CGRP and simple saturation kinetics for amylin, a requirement for phosphodiesterase inhibition to observe elevated hepatocyte cyclic AMP levels and the phosphorylation of Gi-2

Miles D. Houslay, Nicholas J. Morris, Anne Savage, Alison Marker, Mark Bushfield

Journal:

Journal of Cellular Biochemistry

Year:

1994

Language:

english

File:

PDF, 1.70 MB

english, 1994

9

The selective effects of charged local anaesthetics on the glucagon- and fluoride-stimulated adenylate cyclase activity of rat-liver plasma membranes

Larry M. Gordon, Irene Dipple, Richard D. Sauerheber, Judy A. Esgate, Miles D. Houslay

Journal:

Journal of Cellular Biochemistry

Year:

1980

Language:

english

File:

PDF, 641 KB

english, 1980

10

The search for a molecular mechanism for the action of insulin

Miles D Houslay

Journal:

Biochemical Education

Year:

1984

Language:

english

File:

PDF, 666 KB

english, 1984

11

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Matthew D. Cullen, York-Fong Cheung, Miles D. Houslay, Tracy L. Hartman, Karen M. Watson, Robert W. Buckheit Jr., Christophe Pannecouque, Erik De Clercq, Mark Cushman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 136 KB

english, 2008

12

Noradrenergic Activity Differentially Regulates the Expression of Rolipram-Sensitive, High-Affinity Cyclic AMP Phosphodiesterase (PDE4) in Rat Brain

Ying Ye, Marco Conti, Miles D. Houslay, Shakeel M. Farooqui, Ming Chen, James M. O'Donnell

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 1.03 MB

english, 1997

13

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

Graeme B Bolger, Angela McCahill, Stephen J Yarwood, Michael R Steele, Jim Warwicker, Miles D Houslay

Journal:

BMC Biochemistry

Year:

2002

Language:

english

File:

PDF, 602 KB

english, 2002

14

A novel role for cGMP-specific phosphodiesterase, PDE6, in active transport of cGMP

Jonathan P Day, Miles D Houslay, Shireen-A Davies

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

15

Thermotropic lipid phase separations in human platelet and rat liver plasma membranes

Larry M. Gordon, Patrick W. Mobley, Judy A. Esgate, Gary Hofmann, Anthony D. Whetton, Miles D. Houslay

Journal:

Journal of Membrane Biology

Year:

1983

Language:

english

File:

PDF, 1.14 MB

english, 1983

16

Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases

Alison M. Michie, Graham Rena, Margaret M. Harnett, Miles D. Houslay

Journal:

Cell Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 1.37 MB

english, 1998

17

Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats

Malath M. Makhay, Miles D. Houslay, James M. O'Donnell

Journal:

Psychopharmacology

Year:

2001

Language:

english

File:

PDF, 85 KB

english, 2001

18

Disrupting specific PDZ domain-mediated interactions for therapeutic benefit

Miles D Houslay

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 118 KB

english, 2009

19

Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

Marchmont, Robert J., Houslay, Miles D.

Journal:

Year:

1980

File:

PDF, 330 KB

1980

20

Membrane steps

Journal:

Year:

1986

File:

PDF, 140 KB

1986

21

Activation of two signal-transduction systems in hepatocytes by glucagon

Wakelam, Michael J. O., Murphy, Gregory J., Hruby, Victor J., Houslay, Miles D.

Journal:

Year:

1986

File:

PDF, 493 KB

1986

22

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

Wakelam, Michael J. O., Davies, Shireen A., Houslay, Miles D., McKay, Ian, Marshall, Christopher J., Hall, Alan

Journal:

Year:

1986

File:

PDF, 493 KB

1986

23

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

Gawler, Debra, Milligan, Graeme, Spiegel, Allen M., Unson, Cecilia G., Houslay, Miles D.

Journal:

Year:

1987

File:

PDF, 532 KB

1987

24

Putting the lid on phosphodiesterase 4

Houslay, Miles D, Adams, David R

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 367 KB

english, 2010

25

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

George S Baillie, Simon J MacKenzie, Ian McPhee, Miles D Houslay

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 177 KB

english, 2000

26

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

Simon J MacKenzie, George S Baillie, Ian McPhee, Carolynn MacKenzie, Rachael Seamons, Theresa McSorley, Jenni Millen, Matthew B Beard, Gino van Heeke, Miles D Houslay

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 394 KB

english, 2002

27

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells

Malcolm C Shepherd, George S Baillie, David I Stirling, Miles D Houslay

Journal:

British Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 440 KB

english, 2004

28

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness

J. Kirsty Millar, Shaun Mackie, Steven J. Clapcote, Hannah Murdoch, Ben S. Pickard, Sheila Christie, Walter J. Muir, Douglas H. Blackwood, John C. Roder, Miles D. Houslay, David J. Porteous

Journal:

The Journal of Physiology

Year:

2007

Language:

english

File:

PDF, 189 KB

english, 2007

29

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

Hoffmann, Ralf, Baillie, George S., MacKenzie, Simon J., Yarwood, Stephen J., Houslay, Miles D.

Journal:

The EMBO Journal

Year:

1999

Language:

english

File:

PDF, 368 KB

english, 1999

30

[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases

Francis, Sharron H., Conti, Marco, Houslay, Miles D.

Year:

2011

Language:

english

File:

PDF, 201 KB

english, 2011

31

[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Therapeutic Potential of Phosphodiesterase Inhibitors in Parasitic Diseases

Francis, Sharron H., Conti, Marco, Houslay, Miles D.

Year:

2011

Language:

english

File:

PDF, 545 KB

english, 2011

32

Membrane phosphorylation: a crucial role in the action of insulin, EGF, and pp60src?

Miles D. Houslay

Journal:

Bioscience Reports

Year:

1981

Language:

english

File:

PDF, 933 KB

english, 1981

33

Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) zucker rats: Loss of functional G1 and abnormal Gs function

Miles D. Houslay, Debra J. Gawler, Graeme Milligan, Andrew Wilson

Journal:

Cellular Signalling

Year:

1989

Language:

english

File:

PDF, 1.11 MB

english, 1989

34

The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations

Miles D. Houslay

Journal:

Cellular Signalling

Year:

1990

Language:

english

File:

PDF, 930 KB

english, 1990

35

Gi-2 at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: The fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

Miles D. Houslay

Journal:

Cellular Signalling

Year:

1991

Language:

english

File:

PDF, 712 KB

english, 1991

36

Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity

Timothy M. Palmer, Peter V. Taberner, Miles D. Houslay

Journal:

Cellular Signalling

Year:

1992

Language:

english

File:

PDF, 943 KB

english, 1992

37

The role of polybasic compounds in determining the tyrosyl phosphorylation of calmodulin by the human insulin receptor

Mark K. Saville, Miles D. Houslay

Journal:

Cellular Signalling

Year:

1993

Language:

english

File:

PDF, 1.37 MB

english, 1993

38

Molecular cloninc and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

Michael Sullivan, Mark Egerton, Yasmin Shakur, Antje Marquardsen, Miles D. Houslay

Journal:

Cellular Signalling

Year:

1994

Language:

english

File:

PDF, 1.77 MB

english, 1994

39

Dietary linoleic acid-induced changes in respiratory β-adrenergic receptor function and the form of arrhenius plots of isoprenaline- and prostaglandin E2-stimulated adenylate cyclase activity in a model for atopy

Cornelia Loesberg, Sandra Spence, Frans P. Nujkamp, Miles D. Houslay

Journal:

Cellular Signalling

Year:

1994

Language:

english

File:

PDF, 928 KB

english, 1994

40

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram

Alison M Michie, Margaret Lobban, Thomas Müller, Margaret M Harnett, Miles D Houslay

Journal:

Cellular Signalling

Year:

1996

Language:

english

File:

PDF, 1.23 MB

english, 1996

41

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

Miles D. Houslay

Journal:

Year:

2011

Language:

english

File:

PDF, 129 KB

english, 2011

42

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

George S Baillie, Miles D Houslay

Journal:

Current Opinion in Cell Biology

Year:

2005

Language:

english

File:

PDF, 361 KB

english, 2005

43

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Angela McCahill, Theresa McSorley, Elaine Huston, Elaine V. Hill, Martin J. Lynch, Irene Gall, Guy Keryer, Birgitte Lygren, Kjetil Tasken, Gino van Heeke, Miles D. Houslay

Journal:

Cellular Signalling

Year:

2005

Language:

english

File:

PDF, 734 KB

english, 2005

44

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Elaine V. Hill, Catherine L. Sheppard, York-Fong Cheung, Irene Gall, Eberhard Krause, Miles D. Houslay

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 747 KB

english, 2006

45

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1

K. John Smith, George S. Baillie, Eva I. Hyde, Xiang Li, Thomas M. Houslay, Angela McCahill, Allan J. Dunlop, Graeme B. Bolger, Enno Klussmann, David R. Adams, Miles D. Houslay

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 1.15 MB

english, 2007

46

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

Daniel M. Collins, Hannah Murdoch, Allan J. Dunlop, Erik Charych, George S. Baillie, Qi Wang, Friedrich W. Herberg, Nicholas Brandon, Anke Prinz, Miles D. Houslay

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 1.63 MB

english, 2008

47

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

Angela McCahill, Lachlan Campbell, Theresa McSorley, Arvind Sood, Martin J. Lynch, Xiang Li, Chen Yan, George S. Baillie, Miles D. Houslay

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 1.36 MB

english, 2008

48

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Frank Christian, Diana F. Anthony, Surakiran Vadrevu, Tracy Riddell, Jonathan P. Day, Ruth McLeod, David R. Adams, George S. Baillie, Miles D. Houslay

Journal:

Cellular Signalling

Year:

2010

Language:

english

File:

PDF, 1.65 MB

english, 2010

49

A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity

Bryan Serrels, Emma Sandilands, Alan Serrels, George Baillie, Miles D. Houslay, Valerie G. Brunton, Marta Canel, Laura M. Machesky, Kurt I. Anderson, Margaret C. Frame

Journal:

Current Biology

Year:

2010

Language:

english

File:

PDF, 983 KB

english, 2010

50

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells

Theresa McSorley, Eduard Stefan, Volker Henn, Burkhard Wiesner, George S. Baillie, Miles D. Houslay, Walter Rosenthal, Enno Klussmann

Journal:

European Journal of Cell Biology

Year:

2006

Language:

english

File:

PDF, 861 KB

english, 2006